Regulation of blood-brain barrier integrity by microbiome-associated methylamines and cognition by trimethylamine N-oxide.
Lesley HoylesMatthew G PontifexIldefonso Rodriguez-RamiroM Areeb Anis-AlaviKhadija S JelaneTom SnellingEgle SolitoSonia FonsecaAna L CarvalhoSimon R CardingMichael MüllerRobert C GlenDavid VauzourSimon McArthurPublished in: Microbiome (2021)
Our findings demonstrate the mechanisms through which microbiome-associated methylamines directly interact with the mammalian BBB, with consequences for cerebrovascular and cognitive function. Video abstract.