Long-term impact of pre-natal exposure to the Ukraine famine of 1932-1933 on adult type 2 diabetes mellitus.
L H LumeyChihua LiMykola KhalangotNataliia LevchukOleh WolowynaPublished in: medRxiv : the preprint server for health sciences (2023)
Births in the first half-year of 1934 were conceived at the height of the Ukraine famine in 1933. This relation for T2DM outcomes points to early gestation as a critical time window relating maternal nutrition in pregnancy to offspring health in later life. Further studies of biological mechanisms should focus on this time window for which changes in DNA methylation and later body size have also been observed.
Keyphrases
- early life
- dna methylation
- gestational age
- birth weight
- glycemic control
- pregnancy outcomes
- preterm birth
- south africa
- healthcare
- public health
- body mass index
- physical activity
- genome wide
- high fat diet
- preterm infants
- gene expression
- type diabetes
- mental health
- health information
- case control
- pregnant women
- insulin resistance
- copy number
- human health
- risk assessment
- skeletal muscle
- young adults