Progress in Serial Imaging for Prognostic Stratification of Lung Cancer Patients Receiving Immunotherapy: A Systematic Review and Meta-Analysis.
Hwa-Yen ChiuTing-Wei WangMing-Sheng HsuHeng-Sheng ChaoChien-Yi LiaoChia-Feng LuYu-Te WuYuh-Ming ChenPublished in: Cancers (2024)
Immunotherapy, particularly with checkpoint inhibitors, has revolutionized non-small cell lung cancer treatment. Enhancing the selection of potential responders is crucial, and researchers are exploring predictive biomarkers. Delta radiomics, a derivative of radiomics, holds promise in this regard. For this study, a meta-analysis was conducted that adhered to PRISMA guidelines, searching PubMed, Embase, Web of Science, and the Cochrane Library for studies on the use of delta radiomics in stratifying lung cancer patients receiving immunotherapy. Out of 223 initially collected studies, 10 were included for qualitative synthesis. Stratifying patients using radiomic models, the pooled analysis reveals a predictive power with an area under the curve of 0.81 (95% CI 0.76-0.86, p < 0.001) for 6-month response, a pooled hazard ratio of 4.77 (95% CI 2.70-8.43, p < 0.001) for progression-free survival, and 2.15 (95% CI 1.73-2.66, p < 0.001) for overall survival at 6 months. Radiomics emerges as a potential prognostic predictor for lung cancer, but further research is needed to compare traditional radiomics and deep-learning radiomics.
Keyphrases
- lymph node metastasis
- free survival
- contrast enhanced
- deep learning
- end stage renal disease
- squamous cell carcinoma
- ejection fraction
- newly diagnosed
- high resolution
- dna damage
- chronic kidney disease
- magnetic resonance imaging
- prognostic factors
- clinical trial
- systematic review
- peritoneal dialysis
- cell therapy
- machine learning
- case control
- single cell
- computed tomography
- clinical practice
- oxidative stress
- cell proliferation