How to study runs of homozygosity using PLINK? A guide for analyzing medium density SNP data in livestock and pet species.

R MeyermansW GorssenN BuysSteven B Janssens

Published in: BMC genomics (2020)

In this study, we present guidelines for an adequate and robust ROH analysis in PLINK on medium density SNP data. Furthermore, we advise to report parameter settings in publications, and to validate them prior to analysis. Moreover, we encourage authors to report genome coverage to reflect the ROH analysis' validity. Implementing these guidelines will substantially improve the overall quality and uniformity of ROH analyses.

Keyphrases

genome wide
computed tomography
gene expression
healthcare
clinical practice
electronic health record
big data
machine learning
genetic diversity
artificial intelligence