Single-Cell RNA Sequencing Identifies Response of Renal Lymphatic Endothelial Cells to Acute Kidney Injury.

Heidi A Creed Saranya KannanBrittany L TateDavid Godefroy Priyanka Banerjee Brett M Mitchell Ebba Brakenhielm Sanjukta Chakraborty Joseph M Rutkowski

Published in: Journal of the American Society of Nephrology : JASN (2024)

In this study, we uncover lymphatic vessel structural features of captured populations and injury-induced genetic changes. We further determine that lymphatic endothelial cell gene expression is altered between injury models. How lymphatic endothelial cells respond to AKI may therefore be key in regulating future kidney disease progression.

Keyphrases

endothelial cells
high glucose
single cell
lymph node
gene expression
genome wide
rna seq
dna methylation
acute kidney injury
vascular endothelial growth factor
oxidative stress
copy number