Zinc-alpha-2-glycoprotein Secreted by Triple-Negative Breast Cancer Promotes Peritumoral Fibrosis.

Surbhi VermaStephanie D GiagnocavoMeghan C CurtinMenusha ArumugamSandra M Osburn-StakerGuoying WangAaron AtkinsonDavid A NixDavid H Lum James Eric Cox Keren I Hilgendorf

Published in: Cancer research communications (2024)

Functional screening of breast cancer secretomes revealed that triple-negative breast cancer promotes fibrosis in the adipose tissue microenvironment by secreting zinc-alpha-2-glycoprotein and promoting the transdifferentiation of adipocyte stem cells into myofibroblasts.

Keyphrases

adipose tissue
stem cells
insulin resistance
high fat diet
single cell
cell therapy
liver fibrosis
metabolic syndrome
skeletal muscle