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Determination of the effective dose of bone marrow mononuclear cell therapy for bone healing in vivo.

Maren JankoSabrina PöllingerAlexander SchaibleMarlene BellenKatrin SchröderMyriam HeilaniCharlotte FremdlingIngo MarziChristoph NauDirk HenrichRené Danilo Verboket
Published in: European journal of trauma and emergency surgery : official publication of the European Trauma Society (2020)
It was shown that the effective dose of BMC for bone defect healing ranges from 2 × 106 BMC/mL to 1 × 107 BMC/mL. This concentration range seems to be the therapeutic window for BMC-supported therapy of large bone defects. However, further studies are necessary to clarify the exact BMC-dose dependent mechanisms of bone defect healing and to determine the therapeutically effective range more precisely.
Keyphrases
  • bone mineral density
  • bone marrow
  • soft tissue
  • bone loss
  • bone regeneration
  • single cell
  • body composition
  • stem cells
  • cell therapy
  • peripheral blood
  • high resolution
  • density functional theory