Evaluation of the RSR 3 screen ICA™ and 2 screen ICA™ as screening assays for type 1 diabetes in Sweden.

Carina TörnFariba Vaziri-SaniAnita RameliusHelena Elding LarssonSten Anders IvarssonMarie AmorosoJadwiga FurmaniakMichael PowellBernard Rees Smith

Published in: Acta diabetologica (2022)

3 Screen achieved high sensitivity and specificity, suitable for islet cell autoimmunity screening in a healthy population. In the case of 3 Screen positivity, further assays for GADA, IA-2A and ZnT8A are required to check for multiple autoantibody positivity, a hallmark for progression to T1D. In addition, testing for IAA in children below two years of age is warranted.

Keyphrases

high throughput
type diabetes
single cell
young adults
cardiovascular disease
metabolic syndrome
insulin resistance
cell therapy
skeletal muscle