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Single-cell RNA sequencing reveals myeloid and T cell co-stimulation mediated by IL-7 anti-cancer immunotherapy.

Hye Hyeon EumDasom JeongNayoung KimAreum JoMinsu NaHuiram KangYourae HongJin-Sun KongGi Heon JeongSeung-Ah YooHae-Ock Lee
Published in: British journal of cancer (2024)
These results indicate that IL-7 therapy induces anti-tumor immunity by activating T cells and pro-inflammatory myeloid cells, which may have diverse therapeutic applicability.
Keyphrases
  • single cell
  • induced apoptosis
  • rna seq
  • dendritic cells
  • bone marrow
  • acute myeloid leukemia
  • signaling pathway
  • cell cycle arrest
  • high throughput
  • endoplasmic reticulum stress
  • cell death
  • oxidative stress