Cutaneous α-synuclein is correlated with autonomic impairment in isolated rapid eye movement sleep behavior disorder.
Mitchell G MiglisJennifer ZitserLogan Douglas SchneiderEmmanuel DuringSafwan JaradehRoy FreemanChristopher H GibbonsPublished in: Sleep (2022)
In patients with iRBD, the presence of cutaneous p-syn was detected in most patients and was associated with greater autonomic dysfunction on testing. Longitudinal follow-up will aid in defining the predictive role of both skin biopsy and autonomic testing in determining phenoconversion rates and future disease status.