Additive effects of PNPLA3 and TM6SF2 on the histological severity of non-alcoholic fatty liver disease.

Bo Kyung KooSae Kyung JooDonghee KimJeong Mo BaeJeong Hwan ParkJung Ho KimWon Kim

Published in: Journal of gastroenterology and hepatology (2018)

PNPLA3 and TM6SF2 determine the risk of NASH and significant fibrosis, even after adjustment for insulin resistance, and exert an additive effect on NASH and significant fibrosis.

Keyphrases

insulin resistance
liver fibrosis
adipose tissue
type diabetes
metabolic syndrome
polycystic ovary syndrome
skeletal muscle
high fat diet induced
glycemic control