Ex vivo analysis of the contribution of FGF10+ cells to airway smooth muscle cell formation during early lung development.

Elie El AghaVahid KheirollahiAlena MoiseenkoWerner SeegerSaverio Bellusci

Published in: Developmental dynamics : an official publication of the American Association of Anatomists (2017)

Our data demonstrate, in real time, that FGF9 is an important regulator of amplification, migration, and subsequent differentiation of ASMC progenitors during early lung development. The attained results agree with previous findings regarding ASMC formation and highlight the complexity of growth factor signaling networks in controlling mesenchymal cell-fate decisions in the developing mouse lung. Developmental Dynamics 246:531-538, 2017. © 2017 Wiley Periodicals, Inc.

Keyphrases

growth factor
smooth muscle
cell fate
induced apoptosis
stem cells
bone marrow
single cell
cell cycle arrest
transcription factor
electronic health record
cell death
machine learning
big data
mesenchymal stem cells
signaling pathway
endoplasmic reticulum stress
artificial intelligence
label free