Joint Modeling Study Identifies Blood-Based Transcripts Link to Cognitive Decline in Parkinson's Disease.

Junfeng LuoHao WuJinxia LiWenbiao XianWeimin LiJoseph J LocascioZhong PeiGanqiang Liu

Published in: Movement disorders : official journal of the Movement Disorder Society (2022)

Our transcriptome-wide joint modeling analysis uncovered five blood-based transcripts related to cognitive decline in PD. The joint models will serve as a useful resource for clinicians and researchers to screen PD patients with high risk of development of cognitive impairment and pave the path for Parkinson's personalized medicine. © 2022 International Parkinson and Movement Disorder Society.

Keyphrases

cognitive decline
mild cognitive impairment
cognitive impairment
genome wide
gene expression
high throughput
palliative care
dna methylation
drug induced