Clinical Significance of Glomerular Autophagy in Evaluation of Diabetic Kidney Disease Progression.

Xian WangHan-Xu ZengLing JiangXue-Qi LiuYue-Bo HuangYong-Gui Wu

Published in: Diabetes, metabolic syndrome and obesity : targets and therapy (2022)

Autophagy inhibition occurred in both glomeruli and tubules, and was most pronounced in glomerular podocytes. The levels of P62 protein in glomeruli, as an autophagy activity indicator, was one of the predictors of entering the stage of macroalbuminuria in DKD.

Keyphrases

cell death
endoplasmic reticulum stress
signaling pathway
oxidative stress
diabetic nephropathy
high glucose
type diabetes
protein protein