Single-molecule conductance of DNA gated and ungated by DNA-binding molecules.

Takanori HarashimaChie KojimaShintaro FujiiManabu Kiguchi Tomoaki Nishino

Published in: Chemical communications (Cambridge, England) (2018)

The single-molecule conductance of DNA was found to increase by over four fold upon intercalation, while the conductance nearly unaltered upon groove-binding. These effects are interpreted on the basis of the electronic interaction of the DNA-binding molecules with the stacked DNA bases.

Keyphrases

single molecule
dna binding
transcription factor
atomic force microscopy
living cells
binding protein
nucleic acid