Preferential MGMT hypermethylation in SDH-deficient wild-type GIST.

Olivier T GigerRogier Ten HoopenDavid ShorthouseShukri AbdullahiVenkata Ramesh BulusuSaili JadhavEamonn R MaherRuth T Casey

Published in: Journal of clinical pathology (2022)

MGMT promoter hypermethylation occurs exclusively in a subset of dSDH wtGIST. Data from this study support testing of tumour MGMT promoter methylation in patients with dSDH wtGIST to identify those patients who may benefit from most from TMZ therapy.

Keyphrases

wild type
dna methylation
gene expression
transcription factor
genome wide
electronic health record
big data
bone marrow
deep learning
cell therapy