Early Gastric Cancer: Update on Prevention, Diagnosis and Treatment.
Clara Benedetta ContiStefano AgnesiMiki ScaravaglioPietro MasseriaMarco Emilio DinelliMassimo OldaniFabio UggeriPublished in: International journal of environmental research and public health (2023)
Gastric cancer (GC) is a relevant public health issue as its incidence and mortality rates are growing worldwide. There are recognized carcinogen agents, such as obesity, tobacco, meat, alcohol consumption and some dietary protective factors. Strategies of early diagnosis through population-based surveillance programs have been demonstrated to be effective in lowering the morbidity and mortality related to GC in some countries. Indeed, the detection of early lesions is very important in order to offer minimally invasive treatments. Endoscopic resection is the gold standard for lesions with a low risk of lymph node metastasis, whereas surgical mini-invasive approaches can be considered in early lesions when endoscopy is not curative. This review outlines the role of lifestyle and prevention strategies for GC, in order to reduce the patients' risk factors, implement the surveillance of precancerous conditions and, therefore, improve the diagnosis of early lesions. Furthermore, we summarize the available treatments for early gastric cancer.
Keyphrases
- public health
- risk factors
- lymph node metastasis
- minimally invasive
- alcohol consumption
- metabolic syndrome
- type diabetes
- cardiovascular disease
- weight loss
- newly diagnosed
- ejection fraction
- skeletal muscle
- cardiovascular events
- physical activity
- adipose tissue
- chronic kidney disease
- body mass index
- high resolution
- ultrasound guided
- loop mediated isothermal amplification
- patient reported outcomes
- sensitive detection