Intravenous parecoxib for early postoperative cognitive dysfunction in elderly patients: evidence from a meta-analysis.

Jun-Ming HuangZheng-Tao LvBin ZhangWen-Xiu JiangMing-Bo Nie

Published in: Expert review of clinical pharmacology (2020)

Perioperative parecoxib administration is effective in reducing the incidence of POCD and improving the MMSE score compared with control. However, the beneficial effect of parecoxib has been tested only in the Chinese population. Future RCTs in western countries with larger-scale and more comprehensive neurological tests are needed.

Keyphrases

patients undergoing
risk factors
cardiac surgery
south africa
high dose
current status
low dose