TP53 p.Arg337His geographic distribution correlates with adrenocortical tumor occurrence.

Ana Luiza SeidingerIsabel P CaminhaMaria J MastellaroCarmen S GabettaAlexandre E NowillVitória R P PinheiroJosé Andres Yunes

Published in: Molecular genetics & genomic medicine (2020)

We presented for the first time the p.Arg337His frequency among individuals unselected for any disease from a subset of the São Paulo State, the most populous in Brazil. The allele discrimination assay we presented here has proven to be a reliable and efficient method for high-throughput genotyping. ACT was found to be a good sentinel cancer to suppose p.Arg337His presence in our region.

Keyphrases

high throughput
papillary thyroid
single cell
risk assessment
squamous cell
genome wide
gene expression
dna methylation
lymph node metastasis