The role of α1- and α2-adrenoceptor subtypes in the vasopressor responses induced by dihydroergotamine in ritanserin-pretreated pithed rats.

Eduardo Rivera-MancillaVictor H Avilés-RosasGuadalupe Manrique-MaldonadoAlain H Altamirano-EspinozaBelinda Villanueva-CastilloAntoinette MaassenVanDenBrinkCarlos M Villalón

Published in: The journal of headache and pain (2017)

These results suggest that the DHE-induced vasopressor responses in ritanserin-pretreated pithed rats are mediated by α1- (probably α1A, α1B and α1D) and α2- (probably α2A, α2B and α2C) adrenoceptors. These findings could shed light on the pharmacological profile of the vascular side effects (i.e. systemic vasoconstriction) produced by DHE and may lead to the development of more selective antimigraine drugs devoid vascular side effects.

Keyphrases

drug induced
high glucose
diabetic rats
oxidative stress
endothelial cells
stress induced