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Causal linkage between type 2 diabetes mellitus and inflammatory bowel disease: an integrated Mendelian randomization study and bioinformatics analysis.

Xiang XiaoXuanyu WuLu YiFengming YouXueke LiChong Xiao
Published in: Frontiers in endocrinology (2024)
The presence of T2DM does not increase the risk of CRC or IBD. Moreover, T2DM might reduce risk of IBD, including UC. Conversely, the occurrence of CRC or IBD does not influence the risk of T2DM. The association between T2DM and IBD/UC may be related to the changes in multiple metabolic pathways and CTLA-4-mediated immune response.
Keyphrases
  • glycemic control
  • ulcerative colitis
  • immune response
  • bioinformatics analysis
  • type diabetes
  • risk assessment
  • dendritic cells
  • gene expression
  • metabolic syndrome
  • weight loss
  • dna methylation
  • insulin resistance