Evaluation of clinical case definitions for respiratory syncytial virus lower respiratory tract infection in young children.
Janet A EnglundRachel A CohenVeronique BiancoJoseph B DomachowskeJoanne M LangleyShabir A MadhiKhalequ ZamanAgustin BuesoAna CeballosLuis CousinSanjay GandhiOlivier GruselleLisa JoseNicola P KleinAnthonet KoenThanyawee PuthanakiMeng ShiPeter SilasAuchara TangsathapornpongJamaree TeeratakulpisarnTimo VesikariGerco HaarsAmanda LeachSonia K StoszekIlse DieussaertPublished in: Journal of the Pediatric Infectious Diseases Society (2023)
Three case definitions for RSV-LRTI showed high concordance with the WHO 2015 definition, while agreement was lower for severe RSV-LRTI. In contrast to increased respiratory rate, low oxygen saturation was not a consistent finding in RSV-LRTIs and severe RSV-LRTIs. This study demonstrates that current definitions are highly concordant for RSV-LRTIs, but a standard definition is still needed for severe RSV-LRTI.