Rosiglitazone Ameliorates Spinal Cord Injury via Inhibiting Mitophagy and Inflammation of Neural Stem Cells.

Qingqi Meng Zhiteng Chen Qing-Yuan GaoLiqiong HuQilong LiShutai LiLili CuiZhencheng FengXingliang Zhang Shiyun Cui Hai-Feng Zhang

Published in: Oxidative medicine and cellular longevity (2022)

Besides inflammation inhibition, Rosi suppressed mitophagy by reducing FOXO1 to decrease the transcription of PINK1, which played a pivotal role in accelerating the NSC proliferation.

Keyphrases

neural stem cells
signaling pathway
spinal cord injury
oxidative stress
transcription factor
nlrp inflammasome
pi k akt
spinal cord
neuropathic pain
mouse model