Proteasome inhibition reprograms chromatin landscape in breast cancer.

H Karimi Kinyamu Brian D BennettJames M WardTrevor K Archer

Published in: bioRxiv : the preprint server for biology (2023)

Differential Open Chromatin Regions (DOCRs) in breast cancer cells. Proteasome inhibitor sensitive promoters exhibit a distinctive chromatin architecture with discrete transcription initiation patterns.Proteasome inhibition reprograms accessibility of super enhancers.Proteasome inhibitor sensitive super enhancers distinguish basal from non-basal breast cancer subtypes.

Keyphrases

transcription factor
dna damage
gene expression
genome wide
breast cancer cells
minimally invasive
dna methylation
oxidative stress
breast cancer risk