2-Methoxyestradiol inhibits the proliferation level in keloid fibroblasts through p38 in the MAPK/Erk signaling pathway.

Ming-Zi ZhangYi-Fang LiuLi DingZhi-Jin LiYun-Zhu LiLou-Bin SiNan-Ze Yu Xiao-Jun Wang Xiao Long

Published in: Journal of cosmetic dermatology (2023)

The proliferation levels were reduced by both the p38 inhibitor and 2ME2, indicating 2ME2 may achieve an antiproliferation effect by targeting p38 in keloid fibroblasts.

Keyphrases

signaling pathway
pi k akt
induced apoptosis
epithelial mesenchymal transition
extracellular matrix
oxidative stress