Antibiotic Therapy for 6 or 12 Weeks for Prosthetic Joint Infection.
Louis BernardCédric ArvieuxBenoit BrunschweilerSophie TouchaisSéverine AnsartJean-Pierre BruEric OziolCyril BoeriGuillaume GrasJérôme DruonPhilippe RossetEric SennevilleHoucine BentayebDamien BouhourGwenaël Le MoalJocelyn MichonHugues AumaîtreEmmanuel ForestierJean-Michel LaffosseThierry BeguéCatherine ChirouzeFréderic-Antoine DauchyEdouard DevaudBenoît MarthaDenis BurgotDavid BoutoilleEric StindelAurélien DinhPascale BemerBruno GiraudeauBertrand IssartelAgnès CaillePublished in: The New England journal of medicine (2021)
Among patients with microbiologically confirmed prosthetic joint infections that were managed with standard surgical procedures, antibiotic therapy for 6 weeks was not shown to be noninferior to antibiotic therapy for 12 weeks and resulted in a higher percentage of patients with unfavorable outcomes. (Funded by Programme Hospitalier de Recherche Clinique, French Ministry of Health; DATIPO ClinicalTrials.gov number, NCT01816009.).