SYTL2 promotes metastasis of prostate cancer cells by enhancing FSCN1-mediated pseudopodia formation and invasion.

Zean LiYiran TaoZe GaoShirong PengYiming LaiKaiwen LiXu ChenHai Huang

Published in: Journal of translational medicine (2023)

Overall, our study established an FSCN1-dependent mechanism by which SYTL2 regulates the mobility of PCa cells. We also found that the SYTL2-FSCN1-pseudopodia axis may serve as a pharmacological and novel target for treating mPCa.

Keyphrases

induced apoptosis
cell cycle arrest
oxidative stress
signaling pathway