Leukocyte DNA methylation in Alzheimer´s disease associated genes: replication of findings from neuronal cells.
Ida K KarlssonAlexander PlonerYunzhang WangMargaret GatzNancy L PedersenSara HäggPublished in: Epigenetics (2022)
Differences in gene-wide DNA methylation of the Alzheimer's disease (AD)-associated genes BIN1, HLA-DRB5, SORL1, SLC24A4 , and ABCA7 are reported to be associated with AD in post-mortem brain samples. We investigated whether the same associations could be found in leukocytes collected pre-mortem. Using cohort data of 544 Swedish twins (204 dementia diagnoses), we replicated the findings in HLA-DRB5 and SLC24A4 at P < 0.05. However, co-twin control analyses indicated that the associations were partly explained by familial confounding. Thus, DNA methylation differences in HLA-DRB5 and SLC24A4 are present in both neuronal cells and leukocytes, and not fully explained familial factors.
Keyphrases
- dna methylation
- genome wide
- induced apoptosis
- gene expression
- cell cycle arrest
- peripheral blood
- copy number
- genome wide identification
- early onset
- cerebral ischemia
- endoplasmic reticulum stress
- cell death
- signaling pathway
- oxidative stress
- white matter
- brain injury
- resting state
- transcription factor
- functional connectivity
- data analysis