Adipose Tissue Insulin Resistance Predicts the Severity of Liver Fibrosis in Patients with Type 2 Diabetes and NAFLD.

Srilaxmi KalavalapalliEddison Godinez LeivaRomina LomonacoXiaofei ChiSulav ShresthaRachel DillardJeffery BuddJessica Portillo RomeroChristina LiFernando BrilGeorge SamrajJohn PenningtonPetra TownsendFrank OrlandoShwetha ShettyLydia MansourLorena Rodrigues Silva-SombraPierre BedossaJohn MalatyDiana BarbMatthew J GurkaKenneth Cusi

Published in: The Journal of clinical endocrinology and metabolism (2022)

These findings pinpoint to the central role of dysfunctional, insulin-resistant adipose tissue to advanced fibrosis in T2D, beyond simply BMI or steatosis. The clinical implication is that targeting adipose tissue should be the priority of treatment in NAFLD.

Keyphrases

adipose tissue
insulin resistance
liver fibrosis
high fat diet
type diabetes
polycystic ovary syndrome
high fat diet induced
glycemic control
metabolic syndrome
skeletal muscle
body mass index
cancer therapy
weight loss