A polymorphism in the promoter of FRAS1 is a candidate SNP associated with metastatic prostate cancer.
Victoria WangMilan S GeybelsKristina M JordahlTravis GerkeAnis HamidKathryn L PenneySarah C MarktMatthew FreedmanMark PomerantzGwo-Shu Mary LeeHuma RanaDaniela BörnigenTimothy R RebbeckCurtis HuttenhowerRos A EelesJanet L StanfordPractical ConsortiumSonja I BerndtFrank ClaessensKarina D SørensenJong Y ParkAna VegaNawaid UsmaniLorelei MucciChristopher J SweeneyPublished in: The Prostate (2021)
Through its connection with the NFκB pathway, a candidate SNP with a higher frequency in men of African ancestry without cancer was found to be associated with lethal prostate cancer across three well-annotated independent cohorts of Caucasian men.
Keyphrases
- prostate cancer
- radical prostatectomy
- genome wide
- dna methylation
- papillary thyroid
- middle aged
- signaling pathway
- squamous cell carcinoma
- small cell lung cancer
- high density
- gene expression
- transcription factor
- oxidative stress
- lps induced
- squamous cell
- nuclear factor
- pi k akt
- african american
- immune response
- inflammatory response
- childhood cancer
- young adults