MicroRNA-181a as novel liquid biopsy marker of central nervous system involvement in pediatric acute lymphoblastic leukemia.

Bálint EgyedNóra KutszegiJudit C SágiAndrás GézsiAndrea RzepielTamás VisnovitzPéter LőrinczJudit MüllerMarianna ZomboriCsaba SzalaiDániel J ErdélyiGábor T KovácsÁgnes F Semsei

Published in: Journal of translational medicine (2020)

After validating in extensive cohorts, quantification of miR-181a or a specific EV subtype might provide novel tools to monitor CNS disease course and further adjust CNS-directed therapy in pediatric ALL.

Keyphrases

acute lymphoblastic leukemia
blood brain barrier
cell proliferation
long non coding rna
allogeneic hematopoietic stem cell transplantation
stem cells
fine needle aspiration
acute myeloid leukemia
cell therapy
replacement therapy