Effect of levodopa on postural blood pressure changes in Parkinson disease: a randomized crossover study.

Timi EarlAmani JridiPerla C ThulinMeghan ZornKathleen E McKeeKristin MitrovichPaolo MorettiJumana AlshaikhPanagiotis KassavetisMelissa M CortezGuillaume Lamotte

Published in: Clinical autonomic research : official journal of the Clinical Autonomic Research Society (2024)

Levodopa decreases blood pressure in both PD with and without autonomic failure, but it does not cause a greater fall in blood pressure from supine to standing at 3 min. Levodopa-induced baroreflex sympathetic noradrenergic impairment may contribute to lower blood pressure. Lower standing blood pressure with levodopa may increase the risks of fall and syncope.

Keyphrases

parkinson disease
blood pressure
deep brain stimulation
hypertensive patients
heart rate
blood glucose
type diabetes
adipose tissue
high glucose
insulin resistance