Impaired synaptic function is linked to cognition in Parkinson's disease.

Per SelnesAne Løvli StavKrisztina K JohansenAtle BjørnerudChristopher CoelloEirik AuningLisa KalheimIna Selseth AlmdahlErik HessenHenrik ZetterbergKaj BlennowDag AarslandTormod Fladby

Published in: Annals of clinical and translational neurology (2017)

CSF Aβ, α-synuclein, and neurogranin concentrations are related to cortical metabolism and cognitive decline. Synaptic dysfunction due to Aβ and α-synuclein dysmetabolism may be central in the evolution of cognitive impairment in Parkinson's disease.

Keyphrases

cognitive decline
mild cognitive impairment
cognitive impairment
oxidative stress
prefrontal cortex
multiple sclerosis
white matter
cerebrospinal fluid