Multiomics analysis of rheumatoid arthritis yields sequence variants that have large effects on risk of the seropositive subset.
Saedis SaevarsdottirLilja StefansdottirPatrick SulemGudmar ThorleifssonEgil FerkingstadGudrun RutsdottirBente GlintborgHelga WesterlindGerdur GrondalIsabella C LoftSigne Bek SorensenBenedicte A LieMikael BrinkLisbeth ÄrlestigAsgeir Orn ArnthorssonEva BaecklundKarina BanasikSteffen BankLena I BjorkmanTorkell J EllingsenChristian ErikstrupOleksandr FreiInger GjertssonDaniel F GudbjartssonSigurjon A GudjonssonGisli H HalldorssonOliver HendricksJan HillertEstrid HogdallSøren JacobsenDorte Vendelbo JensenHelgi JonssonAlf KastbomIngrid KockumSalome KristensenHelga KristjansdottirMargit H LarsenAsta LinauskasEllen-Margrethe HaugeAnne G LoftBjorn R LudvikssonSigrun H LundThorsteinn MarkussonGisli MassonPall MelstedKristjan H S MooreHeidi Lausten MunkKaspar R NielsenGudmundur L NorddahlAsmundur OddssonThorunn A OlafsdottirPall I OlasonTomas OlssonSisse Rye OstrowskiKim Hørslev-PetersenSolvi RognvaldssonHelga SannerGilad N SilberbergHreinn StefanssonErik SørensenInge J SørensenCarl TuressonThomas BergmanLars AlfredssonTore K KvienSøren BrunakKristján SteinssonVibeke AndersenOle A AndreassenSolbritt Rantapää DahlqvistMerete Lund HetlandLars KlareskogJohan AsklingLeonid PadyukovOle Bv PedersenUnnur ThorsteinsdottirIngileif JonsdottirKari Stefanssonnull nullnull nullnull nullPublished in: Annals of the rheumatic diseases (2022)
Sequence variants pointing to causal genes in the JAK/STAT pathway have largest effect on seropositive RA, while associations with seronegative RA remain scarce.