Chloroquine is a potent pulmonary vasodilator that attenuates hypoxia-induced pulmonary hypertension.

Kang WuQian ZhangXiongting WuWenju LuHaiyang TangZhihao LiangYali GuShanshan SongRamon J AyonHaiyang TangKimberly M McDermottAngela BalistrieriChristina WangStephen M BlackJoe G N GarciaAyako MakinoJason X-J YuanJian Wang

Published in: British journal of pharmacology (2017)

Chloroquine is a potent pulmonary vasodilator that may directly or indirectly block VDCC, store-operated Ca2+ channels and receptor-operated Ca2+ channels in PASMC. The therapeutic potential of chloroquine in pulmonary hypertension is probably due to the combination of its vasodilator, anti-proliferative and anti-autophagic effects.

Keyphrases

pulmonary hypertension
pulmonary artery
pulmonary arterial hypertension
plasmodium falciparum
cell death
protein kinase
coronary artery