LncRNA-AK137033 inhibits the osteogenic potential of adipose-derived stem cells in diabetic osteoporosis by regulating Wnt signaling pathway via DNA methylation.
Shuanglin PengYujin GaoSirong ShiDan ZhaoHuayue CaoTing FuXiaoxiao CaiJingang XiaoPublished in: Cell proliferation (2021)
LncRNA-AK137033 inhibits the osteogenic potential of DOP-ASCs by regulating the Wnt signaling pathway via modulating the DNA methylation level in the sFrp2 promoter region. This study provides an important reference to find new targets for the treatment of bone defects in DOP patients.
Keyphrases
- dna methylation
- signaling pathway
- mesenchymal stem cells
- gene expression
- genome wide
- pi k akt
- cell proliferation
- stem cells
- bone marrow
- bone mineral density
- ejection fraction
- long non coding rna
- newly diagnosed
- type diabetes
- epithelial mesenchymal transition
- induced apoptosis
- wound healing
- long noncoding rna
- human health
- risk assessment
- oxidative stress
- soft tissue
- copy number
- endoplasmic reticulum stress
- climate change
- bone regeneration
- patient reported