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YTHDC1 is downregulated by the YY1/HDAC2 complex and controls the sensitivity of ccRCC to sunitinib by targeting the ANXA1-MAPK pathway.

Wei LiKun YeXurui LiXinlin LiuMou PengFang ChenWei XiongYinhuai WangLiang Zhu
Published in: Journal of experimental & clinical cancer research : CR (2022)
We identified a novel YY1/HDAC2/YTHDC1/ANXA1 axis modulating the progression and chemosensitivity of ccRCC.
Keyphrases
  • signaling pathway
  • histone deacetylase
  • renal cell carcinoma
  • oxidative stress
  • metastatic renal cell carcinoma
  • pi k akt
  • cell proliferation