Highly Efficient Targeting of EGFR-Expressing Tumor Cells with UniCAR T Cells via Target Modules Based on Cetuximab®.
Justyna JureczekAnja FeldmannRalf K BergmannClaudia ArndtNicole BerndtStefanie KoristkaLiliana Rodrigues LoureiroNicola MitwasiAnja HoffmannAlexandra KeglerTabea BartschMichael Philipp BachmannPublished in: OncoTargets and therapy (2020)
Improved efficiency of the scFv-based TM allowed the redirection of UniCAR T cells towards tumor cells expressing high as well as low EGFR levels in comparison to nb-based αEGFR TMs.