Early volumetric, perfusion, and diffusion MRI changes after mutant isocitrate dehydrogenase (IDH) inhibitor treatment in IDH1-mutant gliomas.

Nicholas S Cho Akifumi HagiwaraBlaine S C EldredCatalina RaymondChencai WangFrancesco SanvitoAlbert LaiPhioanh NghiemphuNoriko SalamonLori SteelmanIslam HassanTimothy F CloughesyBenjamin M Ellingson

Published in: Neuro-oncology advances (2022)

Increased nrCBV at 3-6 weeks of treatment may reflect transient therapeutic and/or tumor growth changes, whereas nrCBV, ADC, and FLAIR volume changes occurring at 2-4 months of treatment may more accurately reflect antitumor response to IDH inhibition.

Keyphrases

wild type
magnetic resonance imaging
low grade
computed tomography
high grade
combination therapy
diffusion weighted imaging