Arid5a makes the IL-17A/F-responsive pathway less arid.

The cytokine interleukin-17A/F (IL-17A/F) not only protects the skin and mucosae against Candida albicans infection in mice and humans but also promotes autoimmunity and autoinflammation in mice. In this issue of Science Signaling, Amatya et al report that the RNA binding protein Arid5a promotes responses to IL-17A/F through multiple mechanisms.