A high-resolution mass spectrometric approach to a qualitative and quantitative comparative metabolism of the humantenine-type alkaloid rankinidine.

Meng-Die GongJiao-Yan QinMeng-Ting ZuoXue-Jia QiYong WuXiao-Feng ZhengZhao-Ying Liu

Published in: Rapid communications in mass spectrometry : RCM (2022)

The interspecific metabolic differences of rankinidine in HLMs, PLMs, GLMs and RLMs were compared and studied for the first time using LC/QTOF. These findings will certainly support future studies of rankinidine metabolism in vivo and will contribute to elucidating the cause of species-specific differences behind Gelsemium toxicity.

Keyphrases

high resolution
mass spectrometry
ms ms
oxidative stress
simultaneous determination
case control
high speed
genetic diversity