Pharmacological inhibition of epidermal growth factor receptor attenuates intracranial aneurysm formation by modulating the phenotype of vascular smooth muscle cells.
Yin LuoHaishuang TangZhaolong ZhangRui ZhaoChuanchuan WangWenguang HouQinghai HuangJian-Min LiuPublished in: CNS neuroscience & therapeutics (2021)
These results suggest that EGFR plays a critical role in the initiation of IA and that the EGFR inhibitor erlotinib protects rats from IA initiation by regulating phenotypic modulation of VSMCs.