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Cu-Catalyzed Aminoacyloxylation of Unactivated Alkenes of Unsaturated Hydrazones with Manifold Carboxylic Acids toward Ester-Functionalized Pyrazolines.

Rui-Hua LiuZi-Qing WangBang-Yi WeiJian-Wu ZhangBo ZhouBing Han
Published in: Organic letters (2018)
A copper-catalyzed aminoacyloxylation of unactivated alkenes of unsaturated hydrazones is achieved by using various commercially available carboxylic acids as the acyloxylating reagents and di- tert-butyl peroxide (DTBP) as the oxidant. By using this method, a sequence of structurally diversiform acyloxyl-substituted pyrazolines are efficiently synthesized. Significantly, many carboxyl-containing drugs and bioactive molecules with unprotected functional groups are compatible in this reaction.
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