Early lysosomal maturation deficits in microglia triggers enhanced lysosomal activity in other brain cells of progranulin knockout mice.

Julia K GötzlAlessio-Vittorio ColomboKatrin FellererAnika ReifschneiderGeorg WernerSabina TahirovicChristian HaassAnja Capell

Published in: Molecular neurodegeneration (2018)

The present study uncovers early and selective lysosomal dysfunctions in Grn knockout microglia/macrophages. Dysregulated lysosomal homeostasis in microglia might trigger compensatory lysosomal changes in other brain cells.

Keyphrases

induced apoptosis
inflammatory response
neuropathic pain
white matter
endoplasmic reticulum stress
spinal cord injury
multiple sclerosis
wild type