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Androgen receptor expression in endometrial carcinoma and its correlation with clinicopathologic features.

Atif Ali HashmiZubaida Fida HussainAmna QadriMuhammad IrfanSahar RamzanNaveen FaridiAmir KhanMuhammad Muzzammil Edhi
Published in: BMC research notes (2018)
18/89 (20.2%) cases of endometrial carcinoma showed positive androgen receptor expression. On the other hand, low, moderate and high androgen receptor expression was noted in 7/89 (7.9%), 10/89 (11.2%) and 1/89 (1.1%) cases respectively. 15/77 (19.48%) of endometrioid cancers and 3/7 (42.28%) cases of serous carcinoma showed androgen receptor expression; while none of the cases of clear cell or carcinosarcoma revealed androgen receptor expression. No significant association of androgen receptor expression with various clinicopathologic features of endometrial carcinoma was noted. We found that a significant subset of endometrial cancers express androgen receptor especially a serous cancers; therefore we suggest that androgen receptor expression testing should be done in endometrial carcinoma.
Keyphrases
  • endometrial cancer
  • high grade
  • clear cell
  • single cell
  • long non coding rna
  • childhood cancer