The conundrum of polysubstance overdose.

Joseph V PergolizziAlbert DahanJo Ann LeQuangRobert B Raffa

Published in: Journal of clinical pharmacy and therapeutics (2021)

A new approach to treating opioid-induced respiratory depression due to drug overdose focuses on agents that stimulate respiratory drive rather than competing for opioid receptors. Such an approach is "agnostic" to the cause of the respiratory depression, so might be a potential way to treat polysubstance overdose.

Keyphrases

chronic pain
pain management
depressive symptoms
drug induced
high glucose
emergency department
diabetic rats
oxidative stress
endothelial cells
adverse drug