TLR3 ligation affects differentiation and stemness properties of gingival mesenchymal stem/progenitor cells.

Mohamed MekhemarJohannes TölleChristof DörferKarim Mohamed Fawzy El-Sayed

Published in: Journal of clinical periodontology (2020)

TLR3-mediated activation maintains the mesenchymal stem/progenitor cells phenotype and drives G-MSCs' differentiation and commitment, with a shift away from an undifferentiated pluripotent cellular phenotype. This distinctive modulation could influence potential therapeutic applications of G-MSCs.

Keyphrases

stem cells
mesenchymal stem cells
toll like receptor
bone marrow
inflammatory response
immune response
umbilical cord
epithelial mesenchymal transition
signaling pathway
cell fate