Effects of cyclophosphamide related genetic variants on clinical outcomes of adult hematopoietic cell transplant patients.

Takuto TakahashiRachael PearsonQing CaoAileen ScheibnerKinjal SanghaviDaniel WeisdorfClaudio BrunsteinJohn RogosheskeVeronika BachanovaErica D WarlickAnthony WisemanPamala A Jacobson

Published in: Cancer chemotherapy and pharmacology (2022)

The present study suggests that genetic variants influencing the PKPD of CY may help identify patients at risk for inferior outcomes after HCT using CY-based reduced-intensity conditioning.

Keyphrases

end stage renal disease
ejection fraction
chronic kidney disease
newly diagnosed
peritoneal dialysis
low dose
patient reported outcomes
young adults
cell proliferation
high dose
mesenchymal stem cells
high intensity