Blockade of adrenergic β-receptor activation through local delivery of propranolol from a 3D collagen/polyvinyl alcohol/hydroxyapatite scaffold promotes bone repair in vivo.

Hao WuYue SongJunqin LiXing LeiShuaishuai ZhangYi GaoPengzhen ChengBin LiuSheng MiaoLong BiLiu YangGuo-Xian Pei

Published in: Cell proliferation (2019)

This study demonstrates that local adrenergic β-receptor blockade can effectively enhance the treatment of bone defects by stimulating osteogenic differentiation, inhibiting osteoclastogenesis and enhancing BMSCs migration.

Keyphrases

bone loss
tissue engineering
bone mineral density
bone regeneration
mesenchymal stem cells
soft tissue
signaling pathway
postmenopausal women
binding protein
combination therapy
inflammatory response
wound healing