Molecular pathways in vulvar squamous cell carcinoma: implications for target therapeutic strategies.

null Giulia MantovaniSimona Maria FragomeniFrediano InzaniAnna FagottiLuigi Della CorteStefano GentileschiLuca TagliaferriGian Franco ZannoniGiovanni ScambiaGiorgia Garganese

Published in: Journal of cancer research and clinical oncology (2020)

We suggest adding p16, p53 and HPV status to routine hystopathological examination of vulvar biopsies or surgical specimens. Predictive biomarkers for anti-EGFR and anti-PD-1/PD-L1 drugs are needed. Enough preclinical data supporting anti-angiogenic target therapies in clinical trials are existing. Hormonal receptor expression deserves further investigation.

Keyphrases

squamous cell carcinoma
clinical trial
small cell lung cancer
sentinel lymph node
electronic health record
high grade
tyrosine kinase
clinical practice
big data
stem cells
radiation therapy
lymph node
bone marrow
adipose tissue
study protocol
artificial intelligence